By Ivana Pantelic
The on-going ‘green’ development within the own care coupled with international environmental matters, position natural-origin, biodegradable and skin-friendly surfactants equivalent to alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, enough information has been received to welcome a few sugar emulsifiers into the sphere of drug dosage. Alkyl Polyglucosides provides a entire compendium which publications a researcher from the APG-related preformulation phases to formula processing, together with the research of assorted APG-stabilized structures dermis functionality. This e-book introduces a variety of APG representatives, their advantages with regards to convinced traditional surfactants, physicochemical and interfacial houses, attainable interplay with widespread constituents and various characterization innovations integral for the overview of colloidal structures. the 1st bankruptcy introduces alkyl polyglucosides, via chapters on their houses, behaviour, an outline of the patent safeguard mechanisms and directions for filing patent purposes. ultimately, a end surveys foreign patent functions concerning APGs.
- introduces the sphere of alkyl polyglucoside emulsifiers, directory all of the modern and newly synthesized APG emulsifiers
- provides distinctive details on numerous elements of APG-based constructions
- reveals capability of APG-stabilized autos as potential supply platforms utilizing numerous version medicinal drugs and beauty actives
- includes an updated assessment of study performed within the box of APGs, facilitating destiny preformulation and formula reviews for researchers
- offers a concise and useful compendium of characterization recommendations
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Extra resources for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
Hydrophilic surfactants and water were heated to the same temperature and added to the melted lipid phase. The mixture was dispersed with a high-shear mixer (Ultra Turrax, IKA Staufen, Germany) for 30 s at 8000 rpm and subjected to high-pressure homogenization, applying a pressure of 500 bar. The homogenizer (Micron LAB 40, APV Deutschland GmbH, Germany) was equipped with a water jacket for temperature control. After homogenization, the obtained hot oil/water (o/w) nanoemulsions were transferred into transparent white silanized vials, which were immediately sealed.
G. Polysorbates). This makes the physicochemical behaviour of APGs in oil–water systems distinctly different from that of conventional non-ionics. , 2010). 1 Critical micelle concentration and micelle shape When discussing surfactant behaviour in solution, the keystone is research into their critical micelle concentration (CMC). It is well known that CMC is the concentration above which monomeric surfactant molecules abruptly assemble into aggregates called micelles (Hait and Moulik, 2002). The CMC is useful as it reveals the propensity of the surfactant to assemble in water.
G. water). In water solutions, APGs first aggregate into micelles, and this micellar phase region is usually large. As opposed to polyoxyethylenebased non-ionics, which have two micellar phases (dilute and concentrated), APGs form different types of micelles in these regions. The dilute phase consists of micelles with aggregation number in the range 200–400, whereas the concentrated phase contains larger aggregates, probably branched micelles, which form a network through entanglement. g. SLS) in water, which could solubilize different polar oils more efficiently than individual surfactant systems.