By Derek Leroith (Eds.)
Quantity 2 has fascinated about facets of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. furthermore, thyroid melanoma and steroidogenic enzymes and precocious puberty are coated. eventually, the "hot issues" comprise leptin and progress issue signaling.
Read Online or Download Advances in Molecular and Cellular Endocrinology PDF
Best endocrinology & metabolism books
Sexual distinction within the mind has lengthy been one of many extra exciting study parts within the box of neuroscience. This thorough and accomplished textual content uncovers and explains contemporary neurobiological and molecular organic reviews within the box of neuroscience as they relate to the mechanisms underlying sexual differentiation of the mind.
This quantity seeks to supply a coherent account of the technology of molecular and mobile endocrinology. It covers components akin to endocrine suggestions keep watch over in future health and affliction, insulin resistance and insulin deficiency, the endothelins, and genetic engineering within the research of hormones.
Because the occurrence of early life weight problems keeps to dramatically elevate, the emergence of sort 2 and the expanding occurrence of style 1 diabetes in teenagers exhibit that adolescence diabetes, like grownup onset diabetes, is a fancy and heterogeneous situation featuring new hindrances to the training clinician.
Diabetes mellitus is a really universal affliction that's attaining epidemic proportions because of significant raises within the prevalence of weight problems and the propensity for a sedentary lifestyles. the necessity for physicians to familiarize themselves with all kinds of diabetes is key and the Atlas of Diabetes Mellitus is going a ways towards making the duty more straightforward for either certified physicians and people in education.
Extra resources for Advances in Molecular and Cellular Endocrinology
Mutational analyses of the amphiphilic region of the 3rd ~ helix revealed that glycine ~9 in bovine GH (corresponding to glycine ~2~in the human protein) is important in promoting somatic growth in transgenic mice. , 1995). , 1992). , 1989). , 1987). The human GH-R cDNA has an open reading frame of 638 amino acids, including an 18 amino acid signal peptide; the mature form of the receptor is 620 amino acids in length. , 1988). , 1989). There are several alternative 5' exons that encode the 5' untranslated region of the GH-R mRNA.
1995). , 1995). , 1995). Although the function of tyrosine GH Action 41 phosphorylation of the GH-R remains unclear, y333 and y338 may serve accessory roles as binding sites for some of the src homology 2 (SH2) domain-containing proteins involved with GH-R signal transduction. , 1995). , 1995). , 1995). , 1995). Taken in sum, these findings suggest that the NH2-terminal end of JAK2 is required for association with the cytoplasmic domain of the GH-R, and that the COOH-terminal kinase domain of JAK2 may mediate receptor-activated intracellular signaling.
1996). 8 A. Science 273, 464-471. , & Billestrup, N. (1995). Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function. J. Biol. Chem. 270, 21745-21750. , & Horn, F. (1994). Association of transcription factor APRF and protein kinase Jakl with the interleukin-6 signal transducer gp 130. Science 263, 89-91. , & Schwartz, J. (1994). Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor.