Download Advances in Molecular and Cellular Endocrinology by Derek Leroith (Eds.) PDF

By Derek Leroith (Eds.)

Quantity 2 has fascinated about facets of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. furthermore, thyroid melanoma and steroidogenic enzymes and precocious puberty are coated. eventually, the "hot issues" comprise leptin and progress issue signaling.

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Mutational analyses of the amphiphilic region of the 3rd ~ helix revealed that glycine ~9 in bovine GH (corresponding to glycine ~2~in the human protein) is important in promoting somatic growth in transgenic mice. , 1995). , 1992). , 1989). , 1987). The human GH-R cDNA has an open reading frame of 638 amino acids, including an 18 amino acid signal peptide; the mature form of the receptor is 620 amino acids in length. , 1988). , 1989). There are several alternative 5' exons that encode the 5' untranslated region of the GH-R mRNA.

1995). , 1995). , 1995). Although the function of tyrosine GH Action 41 phosphorylation of the GH-R remains unclear, y333 and y338 may serve accessory roles as binding sites for some of the src homology 2 (SH2) domain-containing proteins involved with GH-R signal transduction. , 1995). , 1995). , 1995). , 1995). Taken in sum, these findings suggest that the NH2-terminal end of JAK2 is required for association with the cytoplasmic domain of the GH-R, and that the COOH-terminal kinase domain of JAK2 may mediate receptor-activated intracellular signaling.

1996). 8 A. Science 273, 464-471. , & Billestrup, N. (1995). Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function. J. Biol. Chem. 270, 21745-21750. , & Horn, F. (1994). Association of transcription factor APRF and protein kinase Jakl with the interleukin-6 signal transducer gp 130. Science 263, 89-91. , & Schwartz, J. (1994). Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor.

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