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By Carlos Rotellar

A short, transparent, sensible, and funny method of acute renal insufficiency.

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Sommers BD, Beard CJ, D’Amico AV (2008) Predictors of patients preferences and treatment choices for localized prostate cancer. Cancer 113:2058–2067 10. Flessing A, Jenkins V, Cat S, Fallowfield L (2006) Multidisciplinary teams in cancer care: are they effective? Lancet Oncol 7(11):935–943 11. Houssami N, Sainsbury R (2006) Breast cancer: multidisciplinary care and clinical outcomes. Eur J Cancer 42(15):2480–2491 12. Davies AR, Deans DAC, Penman I (2006) The multidisciplinary team meeting improves staging accuracy and treatment selection for gastro-esophageal cancer.

Additional truncated forms of proPSA exist in serum, primarily those with leader sequences of 5, 4 and 2 amino acids. Cleavage of the leader sequences by human kallikrein 2 (hkr) and trypsin to activate PSA decreases with decreasing size of the propeptide leader sequence with [À2] proPSA resistant to activation. [À2] proPSA is the most relevant form in tumour extracts and immunohistochemically stains cancer cells more strongly than benign cells [13]. The [À2] proPSA form and the other proPSA forms have been studied individually and in combination and suggest a role for these molecular forms of PSA in the early detection of PCa [14] as well as in discriminating between indolent and lethal cancers [15, 16].

Even though whole mounts of sections from RPS appear not to be superior to sections from standard blocks in detecting adverse pathological features, their use has the great advantage of displaying the architecture of the prostate and the identification and location of tumour nodules more clearly, with particular reference to the index tumour; further, it is easier to compare the pathological findings with those obtained from digital rectal examination (DRE), transrectal ultrasound (TRUS) and prostate biopsies [1–4].

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